Calculate

This tool predicts the risk of seizure recurrence and Chance of an Occurrence of a Seizure in the next Year (COSY) after febrile status epilepticus (FSE), particularly focusing on hippocampal abnormalities detected through MRI. It provides an estimate of seizure recurrence risk and the likelihood of hippocampal sclerosis (HS) or mesial temporal lobe epilepsy (MTLE) based on detailed diagnostic imaging and patient characteristics.

Variables Used:

1. MRI Findings:
   • T2 Hyperintensity: Indicates acute hippocampal inflammation or injury, strongly associated with increased risk of HS and MTLE.
   • Extra-hippocampal Abnormalities: Includes structural issues such as mass lesions or lobar atrophy.
   • Hippocampal Malrotation (HIMAL) or Dysmorphic Hippocampi: Suggests moderate risk due to structural irregularities.
   • T2 Normal: Indicates normal hippocampal appearance with the lowest risk.
2. Time in Months (Slider): Specifies the interval since the FSE to assess longitudinal outcomes, providing seizure risks over different time periods.
3. Risk Fields:
   • Risk of Seizure Recurrence: Displays cumulative risk (%) based on MRI findings and time interval.
   • COSY: Predicts seizure probability changes (%) over a one-year period depending on hippocampal and other MRI abnormalities.

Outputs:

• Risk of Seizure Recurrence: Indicates the likelihood of experiencing another seizure at specific time points after FSE, factoring in MRI-defined hippocampal conditions. For patients with T2 Hyperintensity, the risk of MTLE and recurrent seizures is substantially higher compared to those with normal MRI findings.
• COSY: Reflects the probability of seizure occurrence chance in the next year. For patients with abnormal hippocampal features (e.g., HIMAL or T2 Hyperintensity), COSY predicts higher risks compared to those with normal imaging.