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The “When is it Safe to Return to Driving Following First-Ever Seizure” Tool is designed to assess the safety and timing for resuming driving after a first seizure. It uses clinical and imaging data to calculate individualized risk and provides outputs for both seizure recurrence risk and COSY.

Variables Used:

1. Aetiological Subgroup of First Seizure:
   • Options include:
     • Provoked Systemic: Acute systemic issues, e.g., metabolic disturbances.
     • Provoked CNS Lesion: Structural brain lesions identified via imaging.
     • Unprovoked Idiopathic: No identifiable cause; possibly genetic.
     • Unprovoked Remote Symptomatic: Linked to prior CNS insults like tumors or old strokes.
   • This variable is key to determining seizure recurrence probability.
2. Slider for Time Points in Months:
   • Indicates the time interval in months since the first seizure.
   • This is essential to analyze the longitudinal risk changes over time.

Outputs:

• Risk of Seizure Recurrence: Reflects the likelihood of another seizure occurring within the specified timeframe, adjusted for aetiology.
• COSY (Chance of an Occurrence of a Seizure in the next Year): Predicts the percentage risk of a seizure in the next 12 months